Holistic approach to stop COVID

HOLISTIC APPROACH TO STOP COVID

Mukunda Karmacharya, MD, PhD, OMD, Ac, Diplomate Ac

ABSTRAC

COVID-19 infections have been increasing exponentially and resurging as a pandemic with an uncertain future. In a word, COVID-19 is trying to control our world; we can no longer trust our breathing air, our rain, and our sky under corona pollution; we need to prevent its spread. On February 29, 2020, doctor and writer, Mukunda Karmacharya, M.D., Ph.D., O.M.D., presented two articles to The New York Times with advice to slow its spread and which described how noninfected particles produced during a cough convert into infectious disease with the addition of mRNAs genome during incubation (1,2).
The Cluster was not known at that time, which is presented in Fig.1 below.
CNN:  tweeted often in March,2020.

Fig. 1 Noninfected Particles during cough.
Mukunda Karmacharya, MD, PhD, OMD
Presented in Feb 29,2020
(Now Cluster Partivcles)

When we compare COVID-19, Malaria, Ebola, SARS, and MERS, all of them have induced symptoms like cough, high fever and hemorrhagic outcome. Thus, the fever can be suggested as an ICON parameter for treatment and prevention of COVID-19. Checking fever is very simple, noninvasive and easy to obtain even by the family members of the patient. It is becoming clear that even an elevation of one degree above normal body temperature; 37°C, hemolysis can occur (3). So, the persisting fever above 38°C or 102°F will result in hemolysis. Infected RBC has the histidine rich protein on their membrane which are sticky and adhere to the wall of intravascular capillaries affecting the blood flow. If the fever persists, this will commence into more devastating complications, like thrombosis, microangiopathies, etc (4), causing circulation problems and the related organ will be collapsed.
The most important target of this situation is not the COVID-19, but the hyperthermia or the fever. The main crucial problem is the fever causing hemolysis that brings various complications. I believe that lowering the fever rapidly to normal within an hour the activity of COVID-19 will slow down the process. I believe and suggest start taking herbal antipyretic for prevention even when there is no sign of fever or other symptoms which may come slowly and exaggerated with time. Giving early antipyretic calm down the COVID-19 will help not explode and pollute our environment producing emitted particles. The COVID-19 becomes just the parasite may not harm us Even when the fever is getting intense, we can still escape the complications by rapidly dropping the temperature.
There are many antipyretic and bitter herbs all over the world. Those herbs I would recommend are for example: Boneset, Feverfew, Gentiana Lutea, Raspberry leaf, Arjuna, Chirchiltaj, Neem, Swertia Chirata, Goya, Chaparro Amargosa, Tulsi, Quassia Amara, Phyllanthus Niruri, Annona Muricata, Simarouba Amara, etc. That is, they not only clean the capillaries but also lower the blood pressure and prevent damaging further. From the list above, four different herbs were used to make a strong antipyretic, antiviral, anti-inflammatory and antihypertensive extract, in 2009 ( 5,6,7,8,9,10,11,12,13, 14 ). It has been used for many different ailments, no toxic side effects have been reported during this period of 11 years.
COVID-19 is smarter to induce fever to clog up our most important and abundant intravascular capillaries and knows how to control the world.
At this point, 55 patients treated under the prevention dose of 4cc three times a day in a glassof water of 4-8 oz for 2-4 months, none of them got COVID-19. One pneumonia patient with fever102.89 F could bring down the fever to normal just by giving 6cc of the extract and released from the hospital early.

COVID-19 UPDATE
The mechanism of the COVID -19 is unclear in its present manifestation and the spread producing a possible another pandemic which is uncertain now. Many researchers working hard to find the vaccine all over the world.  The cluster population becoming the source of spread at this point.  We have to shut down the strong activity and monopoly of COVID-19 as soon as possible.  Certainly, every one of us wants to halt its spread and get out of Corona captivity.  But, still out of control.

ACE 2 protein has been identified as the functional receptor for SARS-CoV2 the enveloped virus S protein which can easily access the host cell via ACE 2 protein (13, HammingI.et al). Then the positive stranded RNA genome is release into the cytoplasm, the host cell immediately translation of the virus RNA-dependent RNA- polymerase, which is responsible to produce infectious particles. The infected person starts presenting with fever and chills, cough, SOB, wide range of other symptoms within 2 –14 days after exposure, according to the US CDC and Prevention.  According to NHK special on Corona Virus, July 4 ,2020 the symptoms of cough, fever and -chills may commences after the 5th day of exposure, and with time more severe signs and symptoms appear (14: NHK Special, July,4,)
The high fever or hyperthermia make the COVID-19 a hemorrhagic disease due to the hemolysis. Covid-19 became so famous even The Wall Street Journal, May 8, 2020, presented, how Covid-19 hijacked the body from head to toe, Multi-Front Attack; Lung, ENT, GI track, CV, Nervous system, musculoskeletal system, and Kidney. In the section of strange complications, speculated a recent study in journal “The Lancet” found the evidence the virus attacks endothelial cells which form a layer lining blood vessels and the heart. That makes Covid-19 a vascular disease and lung disease said Mandeep Mehra M.D., the author of the article andexecutive director of the center for advanced Heart Disease at Brigham and Women’s Hospital in Boston, also the author. Also, Andre Goy, a hematology oncologist and chair of the John Theurer Cancer Center at Hackensack Medical Center said “Also, patients are not just presenting the more-common large clots in large blood vessels that can lead to stroke and pulmonary embolisms, but also the constellation of small clots that block blood flow through the tiny blood vessels, known as capillaries throughout the body. These are all severe complications due to Covid-19 (15). These tiny capillaries are most abundant and very important part of our vessels that counts for 99 percent and the rest of one percent are our large vessels.
That is why, the COVID-19 becoming more powerful and virulence producing countless severe complications and lots of casualties. This is all contributed by hemolysis due to the fever.
In the postmortem study of covid-19 patients, the lungs from patients with Covid19 showed distinctive vascular features, consisting of severe endothelial injury associated with the presence of intracellular virus and disrupted cell membranes. Histologic analysis of pulmonary vessels showed wide spread of thrombosis with microangiopathy. Alveolar capillary microthrombi were 9 times as prevalent in patients with Covid19 as in patients with influenza (4, Maximilian Ackermann, M.D., et al, NEJM, July 9,2020).
Two postmortem studies from Ecuador in South America presented Pulmonary vascular thrombosis (15).

HOLISTIC APPROACH:
This article is focused on the holistic approach to prevent the spread of Covid-19.
The pivotal temperature of 37 °C, is taken as the ICON parameter to treat and prevent COVID-19.

Considering the body to get back to normal condition, even when we are in pre-exposure state, or in cluster situation, or presenting sign and symptoms, just taking a simple herbal antipyretic is very beneficial. It is also considered that the patient can start taking the natural extract even when there is no sign of fever, or other sign and symptoms. Early taking antipyretic extract can calm down the COVID-19 and thus slow its process.
The main pathway to infection may be exaggerated due to the persisting extreme hyperthermia which should be dropped rapidly to avoid the disastrous effect of spread and complications. The infection is geared by the fever. As it is simple, just by lowering the fever can achieve a lot of relief to the patients, care givers also to the medical community.
I believe, the two important organs, Liver and Kidney, serve critical functions in regulating and balancing the internal organ network system of our body. In TCM, there are 5 internal organs that are critical for human health. They are Liver, Heart, Spleen, Lung, and Kidney. Herbal medicine that target these five organs to improve one’s health and have been used for more than 2000 year. This is the 5-element theory.

TREATMENTS:
The suggested dose of treatment for prevention is 4 cc every eight hour a day for a week after that once a day for a month.
In hospital setting, care giver and patient plans are suggested as follows.

CARE GIVER
Care giver are suggested to take the prevention dose of 4 cc every 8 hours to prevent.
giving and taking COVID-19 on daily basis.

Doctors and nurses can decide about the doses.

PATIENT
The pivotal body temperature of 37 °C is taken as ICON It is beneficial to give the prevention dose the to the patient entering hospital. If the fever does not increase wait until the fever   changes.
For the temperature between 37°C (98.6 °F) – 38 °C (104 °F) please give 6 cc every 6 hours for a day and check if the temperature is normal, if so, continue for one more day.
For temperature between 38°C (100.4°F) – 40°C (104 °F) please give 6 cc every 6 hours for a day and check if the temperature is normal, if so, continue for one more day. Then get back to prevention dose.
For temperature between 40 °C, (104°F) – 45°C (113°F) or higher, please give 4 cc every 2 hour for two days wait for the temperature to get back to normal. This is the very severe condition, although in vitro the denaturation of the blood occur at 50°C, (122°F), it may start above 45°C in vivo and the duration of the fever matters, I believe.

RESULTS:
55patients have been treated under prevention dose, for 2 – 4 months. The duration of     treatment followed the patient’s preference.  The patient’s names are presented in the same table below. None of the patents got COVID-19.
One pneumonia patient with fever of 102.89°Fcould bring down the fever to normal just by giving 6 cc of antipyretic extract and released from the hospital early. One new patient with COVID-19 positive started taking the antipyretic extract since Aug. 7, 2020. He is doing well.
Table.   List of the patients on antipyretic for 2 – 4 months

Note: Latarga Benigno, 59 yo, male with pneumonia with fever 102.89 F
David Mejia, 49 yo, male with COVID-19 positive

DISCUSSIONS;
Looks like the cluster population is the source of our infections, the signs, and symptoms appear 2 – 5 days after exposure. The US CDC and prevention suggests being in quarantine after positive test result. But we are all in pre-quarantine situation. I believe and suggest start taking natural antipyretic for prevention even when there is no sign of fever or other symptoms that may come slowly and exaggerate with time. Early giving antipyretic calm down the COVID-19 such that it does not explode and pollute our environment producing more cluster population. COVID-19 behave to remain as the regular parasite that may not harm us.
The abnormality of coagulation or fibrinolytic system can cause the hypercoagulable state and  Increase risk of intravascular thrombosis. However, two types of thrombophilias may exist; due to the inherited risk factors or acquired. Most common acquired one is trauma, infection,

pregnancy and others. The patterns of coagulation get severe form in inherited risk factors individual than normal. May get faster unwanted complication of thrombosis comparing to normal individual with COVID-19. Need further study how fever affect coagulation and complications (16).
I have been repeatedly saying that the target should be on the hyperthermia or fever. COVID-19 smart enough to cause hemolysis using fever to invade our intravascular network system which counts for 99 percent of our vessels supporting our health. We have to open our eyes to the reality otherwise, COVID-19 gets the goal to control the whole world. It is a simple thing to take natural antipyretic that does not harm us. I think it is reasonable to try and see for a month.
55 patients on trial at Karma Holistic Center for two to four months showed that no one of them are infected. Even 6 cc of the natural antipyretic could bring the fever of 102.89 °F (39.38° C) to normal in one of my patients with pneumonia and released from the hospital, showing that the natural antipyretic could rapidly drop the temperature to normal. I feel need more trial to protect and prevent.
Why fever cause hemolysis, it is very simple just like in our cooking for a long time after complete dehydration convert into black; that is denaturation of protein, vitamins and minerals in the food. Same thing happens in our blood under hyperthermia and its duration. Two studies (3, 15) in vitro, presented the hemolysis occur with high temperature and increase with higher temperature up to 45°C and increase in exponential pattern at 50°C.
Their plots are presented in Fig. 2 and Fig.3

Fig.2 after C. CHALMERS and W.J. RUSSEL

Confirms that hemolysis occurs at 50°C and increases linearly with time of incubation.However, incubation for up to 1 hour at 45°C and below caused no significant hemolysis.

Fig.3 after N.L. GRESHFELD and M. Murayama

Hemolysis rates of human red blood cells as a function of temperature, plotted as Log(% hemolysis) vs. time .

Is a semilogarithmic plot of the percent rate of hemolysis in whole blood as a function of time for incubation temperatures that vary from 4 to 50°C.

The RBC incubated 4 to 20°C presented the minimal of 0.2% hemolysis and remained

constant throughout the experiment. However, at 37°C after 3 hour showed higher rate of 0.5% and then no change up to the entire experiment.

Interestingly, the hemolysis rate of RBC presented above 37°C increase with increase in temperature and the incubation time. This is very important section to note that in real biological environment how fever cause the hemolysis and the impact of duration of a particular temperature on our body. It should be studied as a fundamental science, as it is involved everywhere from cancer to common cold.

CONCLUSION:
I think our target should be on hyperthermia or fever rather than on COVID-19.
If we can lower the uncontrollable fever rapidly, we can escape the disastrous complications and save lives. Antipyretic can start even before the fever commence. It is nontoxic also try to balance the internal organ network system.
In severe cases, it can be taken for four months continuously, the affected capillaries with less damage can be healed get back to normal function.

However, I do not have enough data for a full study. Although it is small, but I feel a big hope in it. We need to move forward to more trials and studies absolutely ASAP.
I need your help. I know whether I will get this opportunity to present this option to the people. This is a very timely and important option for life. Not just yours or mine but the lives of the whole world. All the global citizens have the right to know what their options are. I know all the researchers are working hard to get away from COVID-19 crisis, already millions of people died before the vaccines is out.
This is just my strong cry and plea–

Reference:

1.  Mukunda Karmacharya, Feb 28, 2020. Some suggestions to slowdown Corona virus spread sent to help@nytimes.com.
2. Mukunda Karmacharya, Feb 29, 2020. Corona – virus-letter with   illustration sent to help@nytimes.com.
3.  N.L. Gershfeld and M. Murayama (1988). Thermal Instability of Red Blood Cell Bilayers Membrane Bilayers :Temperature Dependence Hemolysis;
   J.Membrane Biol. 101, 67-72, 1988ck.
4. Maximilian Ackerman, M.D. et al. Pulmonary Vascular Endothelialitis, Thrombosis, and  Angiogenesis in Covid-19. NEJM, vol.383;2, July 9.
5. Vijay Kumar and Johannes Van Staden (2016, Jan. 12 Published online). A review of Swertia Chirayita (Gentianaceae) as a Traditional Medicinal plant. Front Pharmacol. 2015; 6: 308, PMCID: PMC4709473, PMID. :26793105.
6. Zheng M.S., Lu Z. Y. (1990). Antiviral effect of Mangiferin and iso-mangiferin on herpe simplex virus. Chinese Med J. 103, 160-165.  [ Pub Med] [ Google Scholar].
7. Niiho Y., Yamazaki T., Nakajima Y., Yamamoto T.,Ando H., HiraiY.(2006).Gastroprotective effects of bitter principals isolated from Gentian root and Swertia herb on experimentally induced gastric lesions in    rats. J. Nat. Med. 60, 82-88.
8. Bertani, S., et al, “Quassia  amara L. (Simaroubaceae) leaf tea: Effect of the growing stage and desiccation status on the antimalarial activity of a traditional preparation.” J.Ethnopharmacol.2007 Apr 20;111(1):40-42.
9. Bourinbaiar, A.S., et al. “The activity of plant- derived retroviral proteins MAP30 and GAP31 against Herpes simplex virus in vitro.” Biochem.
10. Mazumdder, A., et al., “Antimicrobial potentiality of Phyllannthus  amarus against drug resistant Pathogens” Nat. Prod. Res.2006;20(4):323.
11. Luna J.S. et al.,”Acetogenins in Annona muricata L. (Annonaceae) are potent Mulluscides” Nat. Prod. Res. 2006;20(3):253-7.
12. Franssen, F.F., et al.,”In vivo andin vitroantiplasmodial activities in some plants traditionally used in Guatemala against malaria” Antimicrob. Agents Chemother.1997;41(7):1500-3.
13. Hamming I. et al., Tissue distribution of ACE2 protein, the functional receptor for SARS corona virus. A first step in understanding SARS pathogenesis. J.Pathol.2004;203::631- 637Sopus 611, Pub Med, Crossref, Google Schola.
14. NHK Special on Corona Virus update, July 4,2020.
15. The Wall Street Journal, Friday May 8,2020.
16. C. CHALMERS et al.,”WHEN DOES BLOOD HAMOLYSE?” Br. J. Anaesth. (1974), 46-74.
17. Amer Wahed, MD, Amita Dasgupta,PhD, DABCC. Hematology and Coagulation;A Comprehensive Review for Board Preparation, Certification and clinical Practice, Elsevier, 2015, 55-56.

HOLISTIC APPROACH TO STOP COVID-19
MUKUNDA KARMACHARYA MD, PhD, OMD, Ac, DIPLOMATE Ac